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Key transcriptomic effects include upregulation of collagen synthesis genes (COL1A1, COL3A1), decorin, antioxidant genes (SOD1, CAT, GPX1), BDNF, neurotrophin receptors, and proteasome/ubiquitin pathway components
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Although routine B12 supplementation in patients on metformin therapy is not the standard of care (279), it is reasonable to monitor vitamin B12 levels in patients on metformin, particularly for individuals on long-term metformin (102
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