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A single-center, double-blinded, randomized controlled study to evaluate the relative efficacy of sublingual and oral vitamin B-complex administration in reducing total serum homocysteine levels

It does not demonstrate clinical efficacy, comprehensive safety, sterility, endotoxin control, or regulatory approval unless those attributes were specifically tested under suitable validated methods and the relevant regulatory requirements were met

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Without adequate intake of B12, vegans can easily develop deficiency over time, leading to symptoms such as fatigue, weakness, constipation, loss of appetite, weight loss, and nerve problems therefore the researchers recommend that vegans and vegetarians should add vitamin B12 to their diet by eating fermented foods, particular types of mushroom that contain the vitamin and B12-enriched vegetables