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That means symptoms involving the stomach and intestines, such as nausea, vomiting, constipation, or diarrhea

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Oral therapy is generally unsuitable for pernicious anaemia or conditions affecting the terminal ileum (where B12 is absorbed), as these patients lack intrinsic factor or have damaged absorption sites

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These insights suggest that colorectal cancer prevention may be most effective when it targets upstream metabolic drivers rather than downstream inflammatory consequences alone