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The enzyme dipeptidyl peptidase 4 (DPP4) is responsible for breaking down incretins

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However, long-acting GCG receptor (GCGR) agonists have also been shown to dose-dependently stimulate insulin secretion and enhance energy expenditure and fatty acid oxidation, leading to substantial weight loss in rodents [4, 5]

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However, there are specific exceptions for certain medical conditions: Wegovy: Prior authorization requests will be considered only for patients with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) or cardiovascular disease

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