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Other chemical modifications include increasing the size of the hormone or promoting non-covalent attachment to serum albumin, thus extending the plasma circulation time [18, 19]
Furthermore, 40.4% of ICSRs involved hospitalized patients, 2.7% resulted in patient mortality, 0.9% led to disability, and 2.8% caused life-threatening reactions, while only 1.7% classified as non-serious outcomes
Bibcode:2022NatCo..13.3455T
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