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236 In addition, high dietary iron regulates the circadian rhythm of hepatic glycogen production through blood-mediated interactions between nuclear receptor subunit 1 group D member 1 and nuclear receptor auxiliary inhibitor 1

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First, it significantly increases the total percentage of the active molecule that successfully enters systemic circulation

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490 Excessive inhibition of Nrf2 may not improve DOX-induced cardiomyopathy due to insufficient promotion of antioxidant gene expression, while its overactivation increases the breakdown of heme and ferrous iron levels in the HO-1-catalyzed manner, promoting ferroptosis