It's not just about the scale reading
Although Qsymia (phentermine + topiramate) is FDA approved for weight loss, taking just topiramate off label still has significant benefits and, having a generic option, is much more affordable, making it a strong candidate for both weight loss and as a maintenance drug to help keep the weight off after a GLP1 regimen
Exendin-4, liraglutide and semaglutide can directly or indirectly stimulate POMC neurons in the ARC, while indirectly inhibiting NPY/AgRP neurons via presynaptic GABAergic neurons [82-84]
- FDA approval secured with shipping via LillyDirect beginning April 6, 2026, followed by retail pharmacy and telehealth availability, positioning Eli Lilly to compete strongly in the oral obesity treatment market
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