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For instance, early trials of hafnium oxide NPs (NBTXR3) in combination with radiotherapy and PD-1 blockade in head and neck squamous cell carcinoma showed signs of immune activation and abscopal effects but only modest clinical efficacy, requiring further validation in larger studies [199]
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Some specific proteins, such as PA28, PA28, and PA200, that act as proteasome regulatory particles can drive Substrate degradation through ubiquitin-independent mechanisms in the 20S proteasome [16,17,18]
The results may differ depending on the initial skin condition.
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