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and Ames, B.N., 2001

They have a disease, not just by elevated BMI, because that could be muscle mass it doesn't have to be body fat

It was also found that the upregulation of -catenin protein in NG2-glia in the hippocampus of 16-week-old db/db mice was significantly alleviated by treatment with XAV-939

Endocrinology 159 (9), 33403350 (2018)