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Notably, despite the presence of severe obesity, large-scale population cohort studies have revealed that individuals with MC4R -deficient obesity exhibit a unique metabolically protective phenotype

The supernatant was then analyzed by HPLC with a Rainin Econosphere ODS C18 column and an acetonitrile/water mobile phase containing 0.1% trifluoroacetic acid

However, no significant changes were observed for LVMI (MD = 3.19, p = 0.60) or diastolic markers ( E / A ratio MD = 0.13, p = 0.47

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