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doi: 10.1200/JCO.21.01815 24 HainsworthJDDaugaardGLesimpleTHbnerGGrecoFAStahlMJet al

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DHODH, a mitochondrial inner membrane enzyme, catalyzes the oxidation of dihydroorotate (DHO) to orotate while transferring electrons to CoQ10, thereby generating CoQ10H 2 that scavenges ROS and phospholipid hydroperoxides (PL-OOHs) within mitochondria and prevents ferroptosis (Mao et al., 2021