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These are uncommon, but they suggest a need for caution in people with known high hematocrit, clotting disorders or myeloproliferative conditions

An updated systematic review and network meta-analysis of GLP-1 receptor agonists and polyagonists ranked retatrutide at or near the top for weight loss among the modern agents, while also flagging that the strongest-effect agents tend to carry the highest adverse-event burden

This applies to both the semaglutide vial and the bacteriostatic water vial

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