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Gentle swirling over 10 to 15 minutes solves most slow-dissolving cases

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Acknowledgements We would like to thank the participants in the study

Confusion and Disorientation: As liver failure progresses, toxins that are normally filtered by the liver accumulate in the bloodstream, leading to confusion and cognitive impairment

242 Additionally, UNA modification at the siRNA terminus improves siRNA stability and silencing efficacy while considerably reducing off-target effects, highlighting its potential in the development of new therapeutic siRNAs