PT-141 acts centrally through melanocortin pathways, rather than peripherally through vascular or tissue mechanisms
E.Guarner-LansV.Daz-DazE.Manzano-PechL.Palacios-ChavarraA.Valdez-VzquezR
The complexity of PD origins, however, has been underscored by recent discussions of brain versus gut first etiology, molecular biomarkers, involvement of S, phenotypic characteristics (such as unilateral vs bilateral, or tremor predominant vs akinetic-rigid vs postural instability, and gait disturbance), and genotyping 3,4,6,7
There is no robust evidence base guiding treatment in the 25-27 range, and essentially no data for BMIs below 25
However, their translational significance in humans remains to be established