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Deletion of MST1/2 or LATS1/2 genes increased nuclear level of YAP/TAZ and expression of downstream genes (Driskill and Pan, 2021)

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Location: Can appear anywhere on the body, but most commonly on the face, back, and shoulders

The best non-diabetic body-composition anchor favors tirzepatide, about 75:25 fat-to-lean loss in its DXA data versus about 62:38 in semaglutides. This is cross-trial evidence, not a head-to-head maintenance-dose DXA result

But compared to ongoing costs of pain management, sleep medications, or dealing with chronic injuries that never fully heal, peptides often save money long-term