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John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial

Supplemental zinc at 50 mg/day for 10 weeks reduced serum copper by 12-18% in healthy adults, according to data from the National Institutes of Health Office of Dietary Supplements [2]

Your body downregulates thyroid function, reduces non-exercise activity thermogenesis (NEAT), and increases muscle catabolism when caloric restriction becomes too severe