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The authors of a randomized clinical trial that enrolled adults with obesity concluded that 68 weeks of once-weekly semaglutide 2.4 mg resulted in a mean change in body of 14.9% compared to 2.4% in adults on placebo [101]

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At the same time, for those individuals with a BMI of 27 who do not have diabetes or cardiovascular disease, driving to alternate treatments may be preferable