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Sermorelin (HGH Releaser): Peptide used to boost natural growth hormone, increasing lean muscle mass and targeting fat reduction
doi: 10.3389/fcvm.2026.1708109 Received 18 September 2025 Revised 16 January 2026 Accepted 19 January 2026 Published 05 March 2026 Volume 13 - 2026 Edited by Rui Providencia, University College London, United Kingdom Reviewed by Marinela Couselo Seijas, Spanish National Centre for Cardiovascular Research, Spain Toluwalase Awoyemi, University of Oxford, United Kingdom Updates Copyright 2026 Liu and Lu
Mechanism of Action: Why It Makes Sense for Athletes Sermorelin binds to GHRH receptors in the anterior pituitary, increasing pulsatile GH release and downstream insulin-like growth factor-1 (IGF-1) production. Growth hormone and IGF-1 influence several systems relevant to performance: Protein synthesis and muscle repair Collagen formation and tendon remodeling Lipolysis and metabolic efficiency Sleep architecture, particularly slow-wave sleep Because GH secretion is naturally highest during deep sleep, sermorelin is typically administered at night to align with this physiology
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