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On the other hand, GSH exerts a negative feedback inhibition on GCL

Notably, these effective concentrations were 16,000-80,000,000 times lower than concentrations of melatonin required for comparable effects, suggesting highly potent regulatory mechanisms rather than simple antioxidant activity

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It is known to enhance growth factor signaling (e.g., increasing receptors for VEGF and PDGF) and upregulate nitric oxide pathways, leading to improved microcirculation in injured tissue [5]