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The two-year study found that the supplementation improved B-vitamin status, decreased homocysteine concentrations, and reduced risk of total fractures compared to placebo (117)

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As defined in the clinical practice guidelines established by Kidney Disease: Improving Global Outcomes (KDIGO), the diagnostic threshold for anemia in CKD is a hemoglobin (Hb) level below 13.0 g/dL for male patients and under 12.0 g/dL for females who are not pregnant (KDIGO, 2024)

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