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Alteration of ATG genes have been found in diabetic mouse models, including the deletion of Atg5 and Atg7 in PTECs, which is associated with the accumulation of damaged mitochondria, tubular cell apoptosis and renal fibrosis (108)

This instability can be particularly problematic during movements that require knee strength and coordination, such as walking, running, or climbing stairs

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Yoshimura RF, Tran MB, Hogenkamp DJ, Ayala NL, Johnstone T, Dunnigan AJ, Gee TK, Gee KW (2017) Allosteric modulation of nicotinic and GABAA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model