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The prescribing information for semaglutide 2.4 mg contains a boxed warning to inform health care professionals and patients about the potential risk for thyroid C-cell tumors

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One of the key clinical questions addressed by this analysis is whether doses of semaglutide and tirzepatide can be considered interchangeable in practice

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Those with severe kidney disease should also use berberine cautiously and under medical supervision, as specific guidance is limited given berberine's status as a supplement rather than a regulated pharmaceutical