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At the systemic level, aging of the immune system has been associated with a low-grade, chronic inflammatory state called inflammaging 7
Preclinical studies suggest that SSAs enhance amyloid clearance via neprilysin activation, attenuate tau pathology through PI3K/Akt signaling, regulate APOE4 expression, and modulate microglial function, thereby protecting synaptic integrity
They offer convenience, flexibility and can easily be incorporated into an existing wellness routine
30,31 In contrast, supplement use was more targeted toward improving energy and reducing inflammation, which better aligns with the medication strategies used in our clinic
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