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It binds to plasma proteins and is transported to tissues

Prednisolone: Although prednisone has reduced the mineralocorticoid effect, the risk of hypokalemia exists and must be taken into account in particular in the following situations: - when potassium-losing diuretic, laxative or amphotericin B have been given concomitantly or when the patient has vomiting or diarrhea

This is glucose-dependent, meaning the effect only occurs when blood sugar is elevated