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Teprotumumab for the Treatment of Active Thyroid Eye Disease

Phase 3 data over longer durations will clarify whether this trajectory continues, plateaus, or converges with tirzepatide

Important safety considerations include risk of acute pancreatitis (seek urgent medical attention for severe, persistent abdominal pain), gallbladder disease, dehydration leading to acute kidney injury with severe gastrointestinal effects, and potential worsening of diabetic retinopathy, particularly with rapid improvement in blood glucose control

Obesity medications approved by the FDA for long-term use include orlistat (Xenical, Alli), phentermine-topiramate ER (Qsymia), naltrexone-bupropion ER (Contrave), liraglutide (Saxenda), semaglutide (Wegovy), tirzepatide (Zepbound), and orforglipron (Foundayo)

Sergey Terushkin, MD, FACS The patients who have the best experience with tirzepatide are the ones who stay in close contact with their care team