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a RWD: real-world data from cohort or registry studies (electronic health records, insurance-claims databases), b SRS: adverse drug reaction evidence from case reports and spontaneous-reporting systems, such as the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and World Health Organization (WHO) VigiBase
The specific historical details in the opening paragraphs, including the 1975 origin, the second-year medical school account, and the name Substancija Boe Pomozi, are the product of that original reporting rather than established common knowledge
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