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Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

The exact mechanism by which metformin affects EAT is unclear but most reasonably attributed to the well-established metabolic effects of metformin, specifically shifting metabolism into fat oxidation and upregulation of thermogenesis (92, 95)

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This targeted activation makes ARA-290 fundamentally different from broad-spectrum anti-inflammatories or standard pain medications that mask symptoms without addressing the underlying damage

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