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To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green
Glutamatergic synapse in autism: A complex story for a complex disorder
The ratio of GSSG to GSH within cells is often used as a marker of oxidative stress, with higher ratios indicating increased cellular oxidation
Vyas S, Zaganjor E, Haigis MC
The cysteine is then converted to glutathione
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