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MEDI7247, an antibody-drug conjugate (ADC) that specifically binds to the extracellular domain of ASCT2, could release its payload pyrrolobenzodiazepine (PBD), promoting DNA damage and tumor cell death (Liu et al., 2018
Just know much of the published data comes from manufacturer-sponsored studies
doi: 10.1016/j.bcp.2004.02.035 33 GaultVAKerrBDHarriottPFlattPR
(Peptide Sciences) Oncology & adjunctive therapy Interestingly, since senescent cells often accumulate in tissues post-chemotherapy and may contribute to relapse or fibrosis, FOXO4-DRI might serve as adjuncts in oncology (preclinical) by clearing therapy-induced senescent cells
At Jan Medical Group, Dr
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