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Furthermore, compound 16 is degraded considerably more slowly in membrane preparations than Ang IV and stimulates proliferation of mouse neural stem cells at low concentrations, supporting a role of IRAP in neurogenesis ( Figure 5 Contrary to the results obtained after modification in the C-terminal of Ang IV where essentially all compounds examined exhibited some activity, oxidative cyclization of the side chains of Cys 1 and Cys 3 and consequently creation of an 11-membered disulfide macrocycle in the N-terminal rendered the inactive compound 20 (Figure 6)

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doi:10.1074/jbc.m710133200

Benzyl alcohol has been utilized in pharmaceutical and laboratory preparations for decades because of its antimicrobial properties

The regulatory mechanism of ROS homeostasis Faced with these challenges from ROS dysregulation, organisms employ multiple mechanisms to preserve intracellular ROS homeostasis [113] (Fig