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In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)
Step 3: Start tirzepatide at 2.5mg weekly
Twenty-eight of them were judged to have moderate depression, and 43 had severe depression
Current Research on GLP-1 Drugs and Muscle Mass A 2022 systematic review in Obesity Reviews found that GLP-1 medication-associated weight loss showed comparable or slightly better muscle preservation than diet-only approaches
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