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Pro-inflammatory cytokines (e.g., IL-1 and TNF), mediators of Th1 and Th17 cells (e.g., IFN and IL-17), and effector mechanisms involving neutrophils, macrophages, and plasma cells are all implicated in the disease process [28, 29]

Summary: GLP-1 medications do not lose their pharmacological effectiveness over time, but weight loss typically plateaus after 612 months due to metabolic adaptation and reduced energy requirements

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