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Conclusion: Choose your injection day based on your weakest days 60% experience an effect peak on day 24 40% experience an even effect throughout the week Weekend challenges inject WednesdayFriday Weekday challenges inject MondayTuesday Stable eating behavior increases both sensitivity and effect The best day to take your GLP-1 injection is the day that gives you the most support on your most challenging days, while you can maintain a stable weekly rhythm.

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In these situations, reassessing tolerance and gradually increasing the dose may restore metabolic benefits

The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo

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