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Early studies indicated an effect on appetite and food intake (259), and subsequent more detailed studies confirmed these effects after intracerebroventricular administration of low doses of the peptide (278, 294)
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265,266 Similarly, the newly identified lncRNA -cell function and apoptosis regulator (Faar) ameliorates obesity-associated -cell dysfunction and apoptosis by upregulating the islet-specific genes ( Ins2 , NeuroD1 , and Creb1 ) by sponging miR-138-5p
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