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Furthermore, elevated ROS can activate the mitogen-activated protein kinase (MAPK) signaling pathway, suppressing the expression of key transcription factors (e.g., pancreatic and duodenal homeobox 1 [PDX1], Musculoaponeurotic fibrosarcoma oncogene homolog A [MAFA]) and disrupting insulin gene transcription, mRNA stability, and protein synthesis [59, 60]

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We recently published a blog post about it: #diabetics #pharma #migraine #glp_1 #pluschem #language_of_chemistry To view or add a comment, sign in Tightening the screws | The Centre cracks down on misuse of GLP-1 drugs after reports of improper practices emerge Should India enforce stricter checks before miracle drugs hit the market? #Healthcare #Pharma #Regulation #India #Drugs To view or add a comment, sign in The potential prolongation of the heart rate-corrected QT (QTc) interval by various drugs may increase the risk of torsades de pointes

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