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Receptor Desensitization Decreased receptor sensitivity following prolonged exposure to agonists

Canfosfamide Canfosfamide, also known as TLK286, is a GSH analogue activated by GSTP1-1 into a GSH derivative and phosphorodiaminate, an alkylating metabolite that forms covalent linkages with DNA (Fig

16.8% average weight loss at 12 mg 2.0% HbA1c reduction at 12 mg Discontinuation due to side effects: 5.1% at 12 mg notably lower than the obesity-only TRIUMPH trials Dysesthesia also lower in this population The lower side-effect rate in the diabetes population is not fully explained yet

This means your appetite will remain suppressed, so as long as you stick to a healthy diet and exercise plan, you can continue to make weight loss progress

You may need prior authorization or proof that cheaper alternatives like metformin were ineffective