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In addition, clinical evidence has shown that continued treatment with GLP-1RA therapy is associated with maintenance of weight loss [10, 47]

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These changes reduce binding to IGF-binding proteins by approximately 90%, extending half-life from 10 minutes (endogenous IGF-1) to 2030 hours

It is essential for patients considering these medications to have open discussions with their healthcare providers regarding the potential side effects

Endotoxin Assay A bacterial endotoxin assay is used to screen for microscopic heat stable remnants shed by Gram-negative bacteria