The authors are also grateful to Leen Assil Companioni (CBmed, Graz, Austria) for designing the figures before submission, Sylvre Durand (Institute Gustave Roussy, Villejuif, France) for spermidine measurements as well as Nathaly Anto Michel (Medical University of Graz, Graz, Austria) and Andrew L
Because of its properties as an antioxidant, and its high intracellular concentration and wide distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well established
We plan purification around highly polar products and closely related impurities rather than assuming a standard small-molecule workflow is sufficient
The runner-up, who Hanes outkicked by only two seconds in what must have been a dramatic finish , was more than 18 years younger
Metabolic Research Laboratories support was provided by the following core facilities: Disease Model Core, Histology Core, Imaging Core and Core Biochemical Assay Laboratory (supported by the MRC, grant no
