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Clinical trials for tirzepatide (Zepbound) have shown: Because Zepbound is approved, its outcomes are better understood in real-world and clinical settings
TRIUMPH-1: the pivotal obesity trial (May 2026) TRIUMPH-1 is the trial that will underpin any obesity licence application
Sequences for MIN6B1 were ON-TARGET plus Non-targeting Control Pool and ON-TARGET plus Mouse Arrb1 and Arrb2 SMARTpools (Dharmacon)
This echoes the findings of a 2013 review, which found neither firm evidence in favor of this hypothesis nor evidence strong enough to rule out any such increased risk. Recent research also points to a link between the GLP-1 receptor agonist semaglutide and worsening diabetic retinopathy (DR)
J Neurosci 33:1582715836
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