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observed the neuroprotective effect of exenatide in both cultured embryonic primary cerebral cortical and ventral mesencephalic (dopaminergic) neurons, while also improving motor activity in MPTP mice [79]
10.3390/jcm8091323 2 BagshawS
To overcome the barriers and to improve the adherence, oral GLP-1 RAs were needed, but oral protein-based drug absorption is limited because of degradation in the stomach due to low pH, proteolytic enzyme activity, and limited permeability across the gastrointestinal (GI) epithelium
It works by mimicking ghrelin, a hormone that stimulates appetite and growth hormone release from the pituitary gland, thereby increasing IGF-1 levels in research subjects