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In the last decades, a great deal of research aimed at clarifying the role played by GSTs in drug resistance, at developing inhibitors to counteract this activity but also at exploiting GSTs for prodrugs specific activation in cancer cells

Although these three peptides are often grouped together, they are quite different in structure, primary mechanism, evidence level, and typical route of use

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GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig

Improved Sleep and Circadium Rhythm: Epithalon (a synthetic peptide) and Epithalamin (a pineal gland extract) significantly improve sleep in older adults by restoring melatonin production