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On the other hand, administration of tirzepatide at a dose of 70 nmol/kg/day, resulted in a significant weight loss associated with shorter femur compared to saline-treated diabetic mice, but no evident alterations of bone microarchitecture or strength [69]

While tirzepatide (sold as Mounjaro and Zepbound ) has dual action on both GLP-1 and GIP receptors and may be more effective for insulin-resistant patients, some individuals still need additional metabolic support

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