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In conclusion, dietary L-carnitine supplementation of 25 g per cow per day led to a balanced distribution of carnitine and -butyrobetaine between bovine blood cells and plasma, but there were only minor effects on gene level and cellular respiration

Additionally, the same detox and metabolism triggered by the above can also cause a partial histamine breakdown and trapping of methylhistamine which can aggravate all the Sx you mention as well

Another physical indicator is decreased urine output

Anxiety-like behavior In male rats, supplementation with leucine (P20-60), did not reduce POS-induced anxiety-like behavior in the OFT at P60 [105]