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The resulting headache feels like a tight band around the head, accompanied by neck stiffness and shoulder pain
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Chronic low-grade inflammation is a common pathological feature of both: metabolic disturbances in patients with DM induce the release of peripheral inflammatory factors, and these inflammatory factors pass through the compromised BBB into the central nervous system (CNS), activating microglia and astrocytes and triggering a neuroinflammatory cascade response, which in turn promotes A deposition in AD and tau protein hyperphosphorylation (Sebastian Monasor et al., 2020
Fatigue and dehydration can play a role
If patients express curiosity about mood benefits from GLP1 receptor agonists, explain that while some evidence exists, current guidelines from organizations such as the American Diabetes Association focus on metabolic outcomes
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