While These figures represent intake inadequacy (dietary intake below the Estimated Average Requirement from food alone), not biochemical deficiency, the takeaway is that nutritional gaps are very common, and I see them in nearly every patient I care for, including women in their 20s and 30s and professional athletes, and most commonly, in women 40 and older
Furthermore, the dopamine metabolism process inherent to vulnerable nigrostriatal neurons intrinsically generates ROS, further damaging mitochondrial complex I and proteasome function, creating a vicious cycle of oxidative stress and neurodegeneration [336]
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cell cycle G 1 /S checkpoint: RB [S612], RB1 [S780]
