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Lpez-Otn et al., Cell, 2023 Backed by Landmark Clinical Trials The efficacy and safety of semaglutide are supported by extensive research, including the large-scale STEP and SELECT clinical trial programs

[PMID: 35799471] PubMed record related to this compound for laboratory literature review

These may include nausea, decreased appetite, vomiting, constipation, diarrhea, bloating, or abdominal discomfort

This effect was suggested to be due to multiple mechanisms, including alteration of the bile acid pool, changes in microbiota composition, improvement of hepatic glucose metabolism, and increased release of incretin hormones (204, 205)

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