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Transcriptional mode of action is constitutive : ERRs occupy their DNA response elements (ERRE, 5'-TNAAGGTCA-3') and recruit transcriptional machinery even in the absence of ligand

Some providers may consider brief dose reduction followed by return to full dose as a receptor resensitization strategy, though evidence for this approach remains limited

Glucose-6-phosphate dehydrogenase and transketolase modulate breast cancer cell metabolic reprogramming and correlate with poor patient outcome

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