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In addition, as a consequence of the increased permeability, substances and microorganisms that should not cross the barrier would cross the barrier and therefore further activate innate immunity (TLRs), leading to greater accumulation of 5-HT and an increase in symptoms [293]

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1 Introduction Oxidative stress, i.e., overproduction of free radicals, is believed to be a significant predictor and/or a source of secondary pathologies in human disease

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