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If an experimental drug reduces disease progression and results in less need to change symptomatic medications, an imbalance in medication changes between groups can potentially mask or underestimate the true benefits of the new therapy 8

Animal studies further indicate that chronic paternal exposure to anabolicandrogenic steroids prior to conception may alter sperm-borne epigenetic signatures and adversely affect fertility-related outcomes in offspring, although direct evidence in humans remains limited and requires further investigation (80)

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Your healthcare provider may suggest a lower maintenance dose if you cannot tolerate this dose

The Inclusivity Barrier: For an emerging biotech or a university spinout to challenge a Novo Nordisk or Eli Lilly patent, they would need enormous legal capital