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To provide the cell with ribose-5-phosphate (R5P) for the synthesis of the nucleotides and nucleic acids

Full-length GSDME mediates pyroptosis independent from cleavage

Treatment with either lovastatin or lapaquistat appeared to reduce squalene levels even further, as they both target enzymes upstream of squalene synthesis, while conversely, NB-598 treatment produced at least a 100-fold increase in squalene levels in host cells (Fig 3D, right)

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[39] Serotonin, an essential neurotransmitter, is further converted into N -acetylserotonin by the action of serotonin N -acetyltransferase, using acetyl-CoA